Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody
نویسندگان
چکیده
منابع مشابه
Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody
RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW<15 kDa) f...
متن کاملImproved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling.
UNLABELLED Nanobodies are approximately 15-kDa proteins based on the smallest functional fragments of naturally occurring heavy chain-only antibodies and represent an attractive platform for the development of molecularly targeted agents for cancer diagnosis and therapy. Because the human epidermal growth factor receptor type 2 (HER2) is overexpressed in breast and ovarian carcinoma, as well as...
متن کاملDuration of anti-HER2 blockage therapy may improve survival in HER2 positive metastatic breast carcinoma patients.
PURPOSE The duration of anti-HER2 blockage therapy in metastatic breast cancer patients is still unclear. We aimed to evaluate the effect of the anti-HER2 blockage therapy duration and other factors on survival in HER2 positive metastatic breast carcinoma (MBC) patients. METHODS The medical records of 193 HER2 positive MBC patients, who did not have the opportunity to receive adjuvant trastuz...
متن کاملTargeting HER2-breast tumors with scFv-decorated bimodal nanoprobes
BACKGROUND Recent advances in nanomedicine have shown the great interest of active targeting associated to nanoparticles. Single chain variable fragments (scFv) of disease-specific antibodies are very promising targeting entities because they are small, not immunogenic and able to bind their specific antigens. The present paper is devoted to biological properties in vitro and in vivo of fluores...
متن کامل113: Specific Targeting of Her2-positive Breast Cancer Cell Line (sk-br3) Using Idarubicin-loaded Anti-her2 Immunoliposome
Cytotoxic chemotherapy drugs which are used for treating malignant cells cannot distinguish between normal and cancerous cells. This would lead to adverse side effects. Moreover, drug resistance is another major problem of the classical chemotherapy during the treatment period. Recently, various therapeutic strategies have been developed for cellspecific targeting of anti-neoplastic drugs. Amon...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nuclear Medicine and Biology
سال: 2013
ISSN: 0969-8051
DOI: 10.1016/j.nucmedbio.2012.08.008